Chromatography enabling translational pharmacogenomics for Personalized Medicine, and forensic toxicology for Personalized Justice
Steven H. Wong, Ph.D., Professor of Pathology, and Director, Toxicology, Therapeutic Drug Monitoring, Pharmacogenomics and Proteomics, Department of Pathology, Medical College of Wisconsin, and Scientific Director, Milwaukee County Medical Examiner’s Office, Milwaukee, WI 53226
Chromatographic analysis has played a pivotal, enabling role in the era of genomics medicine for the emerging practices of Personalized Medicine and Personalized Justice. In optimizing some drug therapies, chromatographic analyses of drugs and metabolites concentrations complement and enhance genomic and other molecular diagnostics such as in the areas of addiction and pain management. By genotyping the patient’s drug metabolizing enzyme genes in combination with the drug concentrations obtained by chromatographic or other analyses, optimal dosing might be achieved with minimal toxicity as proposed in the emerging practice of Personalized Medicine.
Another application is the use of pharmacogenomics to interpret elevated drug concentrations identified in drug death certification for forensic pathology/toxicology. Drug metabolizing enzyme genes deficiencies or duplications might result in elevated parent drug or metabolites concentrations and hence, toxicity. Toxicological analyses often include drug concentration determinations by chromatographic analyses. Together, the use pharmacogenomics enabled by chromatographic analysis offers the emerging practice of molecular autopsy, enabling the emerging practice of Personalized Justice. This forensic application, as in the use of molecular diagnostics in identify testing using DNA analysis, expands the use of pharmacogenomics and other molecular diagnostics in understanding the genetic effect-contribution to performance and behavior in future legal proceedings. The presentation will include studies and interesting cases.
Biography for Steven H. Y. Wong, Ph.D. DABCC(TC), FACB
Medical College of Wisconsin, Milwaukee, WI
Steven H. Y. Wong, Ph.D.
Dr. Wong is Professor of Pathology, Psychiatry and Behavioral Medicine, and Population Health – Epidemiology., and Director, Toxicology, TDM, Pharmacogenomics and Proteomics, Pathology Dept., Medical College of Wisconsin, and Toxicology Scientific Director at the Milwaukee County Medical Examiner’s Office. He received his Ph.D. in Nuclear Chemistry from Virginia Polytechnic Institute and State University. He was an Associate Professor of Laboratory Medicine at University of Connecticut School of Medicine, and an Associate Professor of Pathology at Johns Hopkins University School of Medicine. His scientific and clinical interests encompass inter-related areas of TDM, toxicology, pharmacogenomics, pharmacoproteomics, Personalized Medicine and Personalized Justice. He is the principal investigator of a multicenter study for assessing pharmacogenomics for certifying 1100 methadone fatalities. In addition to over 114 publications and 138 abstracts, he edited/co-edited four books, with the most recent: Pharmacogenomics and Proteomics: Enabling the Practice of Personalized Medicine. He serves on editorial boards for TDM, Clinical Chemistry and Laboratory Medicine, Annuals of Clinical & Laboratory Science, the Egyptian Journal of Hospital Medicine, and Pharmacogenomics., and a reviewer for NIH grants. He is a member of the National Academy of Clinical Biochemistry, International Association for TDM and Clinical Toxicology (Founding President), Society of Forensic Toxicologists, American Academy of Forensic Sciences (Associate Member), and the American Association for Clinical Chemistry (AACC). He has been active in AACC, currently serving as the chair-elect of the Proteomic Division, past chairs of TDM-T and Molecular Pathology Divisions, Board of Director, and a candidate for President-Elect in 2006.
LC School Reviews
“I now have a better understanding of how HPLC works and why column choice is so important.”
“It is a fantastic course for learning the theory of LC and method development”
“The instructor, Merlin Bicking, is very helpful. It was great to see how wiling he is to answer questions and all the variety of methods he worked on.”
“I am just beginning my position from out of school. I found the course very insightful in terms of preparation for my future career”
“It is very useful for me because having hands on experience, which helped me to understand more of HPLC.”
“Great class. Would easily take again and recommend Dr. Merlin anytime. Would love to take his other courses. If he had a book would quickly buy for reference.”
Steven H. Wong, Ph.D.
Chromatography enabling translational pharmacogenomics for Personalized Medicine, and forensic toxicology for Personalized Justice
Steven H. Wong, Ph.D., Professor of Pathology, and Director, Toxicology, Therapeutic Drug Monitoring, Pharmacogenomics and Proteomics, Department of Pathology, Medical College of Wisconsin, and Scientific Director, Milwaukee County Medical Examiner’s Office, Milwaukee, WI 53226
Chromatographic analysis has played a pivotal, enabling role in the era of genomics medicine for the emerging practices of Personalized Medicine and Personalized Justice. In optimizing some drug therapies, chromatographic analyses of drugs and metabolites concentrations complement and enhance genomic and other molecular diagnostics such as in the areas of addiction and pain management. By genotyping the patient’s drug metabolizing enzyme genes in combination with the drug concentrations obtained by chromatographic or other analyses, optimal dosing might be achieved with minimal toxicity as proposed in the emerging practice of Personalized Medicine.
Another application is the use of pharmacogenomics to interpret elevated drug concentrations identified in drug death certification for forensic pathology/toxicology. Drug metabolizing enzyme genes deficiencies or duplications might result in elevated parent drug or metabolites concentrations and hence, toxicity. Toxicological analyses often include drug concentration determinations by chromatographic analyses. Together, the use pharmacogenomics enabled by chromatographic analysis offers the emerging practice of molecular autopsy, enabling the emerging practice of Personalized Justice. This forensic application, as in the use of molecular diagnostics in identify testing using DNA analysis, expands the use of pharmacogenomics and other molecular diagnostics in understanding the genetic effect-contribution to performance and behavior in future legal proceedings. The presentation will include studies and interesting cases.
Biography for Steven H. Y. Wong, Ph.D. DABCC(TC), FACB
Medical College of Wisconsin, Milwaukee, WI
Dr. Wong is Professor of Pathology, Psychiatry and Behavioral Medicine, and Population Health – Epidemiology., and Director, Toxicology, TDM, Pharmacogenomics and Proteomics, Pathology Dept., Medical College of Wisconsin, and Toxicology Scientific Director at the Milwaukee County Medical Examiner’s Office. He received his Ph.D. in Nuclear Chemistry from Virginia Polytechnic Institute and State University. He was an Associate Professor of Laboratory Medicine at University of Connecticut School of Medicine, and an Associate Professor of Pathology at Johns Hopkins University School of Medicine. His scientific and clinical interests encompass inter-related areas of TDM, toxicology, pharmacogenomics, pharmacoproteomics, Personalized Medicine and Personalized Justice. He is the principal investigator of a multicenter study for assessing pharmacogenomics for certifying 1100 methadone fatalities. In addition to over 114 publications and 138 abstracts, he edited/co-edited four books, with the most recent: Pharmacogenomics and Proteomics: Enabling the Practice of Personalized Medicine. He serves on editorial boards for TDM, Clinical Chemistry and Laboratory Medicine, Annuals of Clinical & Laboratory Science, the Egyptian Journal of Hospital Medicine, and Pharmacogenomics., and a reviewer for NIH grants. He is a member of the National Academy of Clinical Biochemistry, International Association for TDM and Clinical Toxicology (Founding President), Society of Forensic Toxicologists, American Academy of Forensic Sciences (Associate Member), and the American Association for Clinical Chemistry (AACC). He has been active in AACC, currently serving as the chair-elect of the Proteomic Division, past chairs of TDM-T and Molecular Pathology Divisions, Board of Director, and a candidate for President-Elect in 2006.
LC School Reviews
“I now have a better understanding of how HPLC works and why column choice is so important.”
“It is a fantastic course for learning the theory of LC and method development”
“The instructor, Merlin Bicking, is very helpful. It was great to see how wiling he is to answer questions and all the variety of methods he worked on.”
“I am just beginning my position from out of school. I found the course very insightful in terms of preparation for my future career”
“It is very useful for me because having hands on experience, which helped me to understand more of HPLC.”
“Great class. Would easily take again and recommend Dr. Merlin anytime. Would love to take his other courses. If he had a book would quickly buy for reference.”